Dr. Wei Guo is currently a Research Assistant Professor in the Department of Mechanical Engineering at the University of Hong Kong (HKU), in synergy with the Microfluidics and Soft matter group led by Prof. Anderson Shum. He obtained his B.S. and MSc. from Northwestern Polytechnical University, Ph.D. from the University of Hong Kong under the supervision of Prof. Anderson Shum.

Dr. Guo’s group aims to decipher the formation, properties, and functions of biomolecular condensates using both experimental and theoretical methods, in collaboration with simulation teams. His research focuses on phase-separating multicomponent droplets composed of biopolymers such as DNA and RNA. These microdroplets exhibit remarkable physical properties, including ultra-low interfacial tension, unique micropolarity, and tunable rheologies and morphologies—all of which depend on droplet composition and can be programmed through DNA or RNA sequences. Additionally, these droplets serve as excellent model systems for membraneless organelles in cells, with implications for understanding genome organization, diseases, the origins of life, and practical applications such as drug delivery carriers. Dr. Guo is also an expert in droplet microfluidic-based high-throughput systems, which he combines with directed evolution to screen for new RNA aptamers with enhanced fluorescence properties in vivo.